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Literature summary extracted from

  • Davignon, J.; Dubuc, G.
    Statins and ezetimibe modulate plasma proprotein convertase subtilisin kexin-9 (PCSK9) levels (2009), Trans. Am. Clin. Climatol. Assoc., 120, 163-173.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.61 A433T is associated with a plasma PCSK9 concentration of 222 ng/ml Homo sapiens
3.4.21.61 G365R is associated with a plasma PCSK9 concentration of 205 ng/ml Homo sapiens
3.4.21.61 Q190R is associated with a plasma PCSK9 concentration of 55 ng/ml Homo sapiens
3.4.21.61 R434W is associated with a plasma PCSK9 concentration of 51 ng/ml Homo sapiens
3.4.21.61 R46L is associated with a plasma PCSK9 concentration of 51-59 ng/ml Homo sapiens
3.4.21.61 R53V is associated with a plasma PCSK9 concentration of 39 ng/ml Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.61 Homo sapiens Q8NBP7
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.61 blood plasma in healthy volunteers, there is no significant difference in plasma PCSK9 measured between men and women Homo sapiens
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Synonyms

EC Number Synonyms Comment Organism
3.4.21.61 PCSK9
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 Homo sapiens
3.4.21.61 proprotein convertase subtilisin kexin-9
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 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.21.61 Homo sapiens PCSK9 levels correlate with plasma cholesterol, LDL-C, triglycerides, fasting glucose, age and body mass index. In hypercholesterolemic patients, circulating PCSK9 is higher than in healthy volunteers, and increases with increasing statin dose, and further increased when ezetimibe is added. Ezetimibe treatment of Hep-G2 (hepatocytes) and Caco-2 (enterocytes) cells causes a slight increase in PCSK9 mRNA, but no significant rise in PCSK9 protein secretion, suggesting that these transformed cells are not ideal model cell lines up